Humalog is a rapid-acting insulin used to treat people with type 1 or type 2 diabetes.
Watch the Instructions for Use (IFU) Video or read the IFU included with your pen prior to practicing your skills on this module.
Please read the full Instructions for Use included with your Humalog U-100 KwikPen.
Select a skill to begin. Subsequent steps will unlock as you progress.
1. Preparing Your Pen
2. Priming Your Pen
3. Selecting Your Dose
4. Choosing an Injection Site
5. Giving Your Injection
This training is not meant to be a substitute for the Instructions for Use videos, which are the recommended resources to follow during the injection process.
Indication and Safety Summary
Humalog® (HU-ma-log) is a fast-acting insulin used to control high blood sugar in adults and children with diabetes.
Humalog comes in two strengths: U-100 (100 units per milliliter) and U-200 (200 units per milliliter). The Humalog U-200 prefilled pen contains 2 times as much insulin per 1 milliliter as standard (U-100) insulin. The dose window on the pen shows your insulin dose.
It is not known if Humalog is safe and effective for children with type 2 diabetes or for children younger than 3 years of age with type 1 diabetes. There were no studies done with Humalog in these groups of children. If your doctor decides to give your child Humalog, he or she may give you special instructions.
Safety Summary with Warnings
Warnings -
Do not take Humalog if you have:
symptoms of low blood sugar (hypoglycemia)
an allergy to insulin lispro or any of the ingredients in Humalog.
Do not reuse needles or share your insulin injection supplies with other people. This includes your:
prefilled pen for use by a single patient
cartridges
reusable pen that works with Lilly 3mL cartridges
needles
syringes
You or the other person can get a serious infection. This can happen even if you change the needle.
Do not change the type of insulin you take or your dose, unless your doctor tells you to. This could cause low or high blood sugar, which could be serious.
Do not use a syringe to remove Humalog from your prefilled pen. This can cause you to take too much insulin. Taking too much insulin can lead to severe low blood sugar. This may result in seizures or death.
Humalog may cause serious side effects. Some of these can lead to death. The possible serious side effects are:
Low blood sugar. This can cause:
dizziness or light-headedness
sweating
confusion
headache
blurred vision
slurred speech
shakiness
fast heartbeat
anxiety
irritability
mood change
hunger
If you are at risk of having severely low blood sugar, your doctor may prescribe a glucagon rescue medication. These are used when your blood sugar becomes too low and you are unable to take sugar by mouth. Glucagon helps your body release sugar into your bloodstream.
Severe allergic reaction.
Get emergency help right away if you have:
a rash over your whole body
trouble breathing
a fast heartbeat
sweating
a faint feeling
shortness of breath
extreme drowsiness
dizziness
confusion
swelling of your face, tongue, or throat
Low potassium in your blood. This can lead to severe breathing problems, irregular heartbeat, and death.
Heart failure. Taking diabetes pills called thiazolidinediones (thIE-uh-zOH-li-dEEn-dIE-OHns), or “TZDs,” with Humalog may cause heart failure in some people. This includes people who do not have any heart problems. If you have heart failure, it may get worse if you take TZDs with Humalog. Tell your doctor if you have any new symptoms of heart failure, or if they get worse. Some symptoms of heart failure include: shortness of breath, swelling of ankles and feet, and sudden weight gain. Your doctor may need to change or stop treatment with TZDs and Humalog.
High blood sugar and ketoacidosis. You can have these serious problems when your insulin pump or infusion set stops working. They can also happen if your insulin is no longer effective. For these reasons, always keep extra insulin injection supplies with you.
Common side effects
The most common side effects of Humalog are:
low blood sugar
allergic reactions
reactions where you have injected insulin
changes in fat tissue where you have injected insulin
swelling of your hands or feet
weight gain
itching
rash
These are not all of the possible side effects. Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Before using
Talk with your doctor about low blood sugar and how to manage it. Also tell your doctor:
about all of the medicines you take, including over-the-counter medicines, vitamins, and herbal supplements.
about any other prescription medicines you take, especially ones called TZDs.
about all of your medical conditions, including if you have heart failure or other heart, liver, or kidney problems.
if you are pregnant, breastfeeding, or plan to become pregnant or breastfeed.
How to take
Read the Instructions for Use that come with your Humalog. Be sure to take Humalog and check your blood sugar levels exactly as your doctor tells you to. Your doctor may tell you to change your dose because of illness, increased stress, or changes in your weight, diet, or physical activity level. He or she may also tell you to change the amount or time of your dose because of other medicines or different types of insulin you take.
Before injecting Humalog
You can inject your insulin dose yourself, or you can have a trained caregiver inject it for you. Make sure you or your caregiver:
Check the insulin label before each injection. This will help you make sure that you are taking the correct insulin.
Use a new needle for each injection. You can get a serious infection or the wrong dose of insulin if you re-use needles.
Change (rotate) where you inject your insulin with each dose. This can reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin. Do not inject your insulin into the exact same spot or where the skin has pits or lumps. Avoid injecting into thickened, tender, bruised, scaly, hard, scarred, or damaged skin.
When you are ready to inject
Inject Humalog under your skin within 15 minutes before or right after you eat a meal.
Staying safe while taking Humalog
To stay safe while taking your insulin, be sure to never inject Humalog U-200 in your vein, muscle, or with an insulin pump. Also be sure not to:
mix Humalog U-200 with other insulins or liquids.
drive or use heavy machinery until you know how Humalog affects you.
drink alcohol or use other medicines that contain alcohol when taking Humalog.
Learn more
Humalog is a prescription medicine. For more information, call 1-800-545-5979 or go to www.humalog.com.
This summary provides basic information about Humalog. It does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other health care provider about Humalog and how to take it. Your doctor is the best person to help you decide if this medicine is right for you.
HI CON BS 30MAR2026
Humalog® is a registered trademark owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
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